PREDICTORS OF HEPATOCYTES CYTOLYSIS OF INSULIN RESISTANT RATS UNDER CONDITIONS OF PRE- AND POSTNATAL IODINE DEFICIENCY

Carbohydrate metabolism markers, thyroid profile indexes, transaminase activity and structural features of liver were studied, taking into account sexual dimorphism, in rats which keeping on a high-fructose diet under conditions adequate iodine supply pre- postnatal deficiency. It was found that fructose loading animals with deficiency the risk insulin resistance (IR) development increases (HOMA-IR index insulin-resistant male respectively by 22 13% compared to data received high-carbohydrate supply). is important, males females IR, secretion free triiodothyronine decreased 36 40%, thyroid-stimulating hormone – 28 34%, respectively, intact animals. The IR accompanied activation aminotransferases blood serum (more males). In particular, deficiency, aspartate aminotransferase increased 2.7 2.4 times, alanine 3.9 led decrease de-Ritis significantly against background prenatal 25%) relation standard diet. deprivation higher than isolated 11-56% 13-47 %. presence binucleated hepatocytes diffuse number glycogen granules them accumulation glycoproteins wall vessels found. foci fatty dystrophy pronounced zonal character dystrophic processes identified females, prevailed males. cytoplasm lightening granularity, single observed. Under these conditions, average perimeter (by 74%) area three times) hepatocytes, nucleus 3.1 times), 50%) 66%) nucleolus control values. changes consistent an increase activity. Thus, acts as trigger for cytolysis especially prenatal.